@ endo
2025-01-22 16:37:08
If you are a researcher in the field of medicine, you are most likely very familiar with PubMed – where you get citations for the articles and studies that drive your work forward. PubMed Central (PMC), the full-text repository of life sciences journal literature managed by the National Library of Medicine (NLM), was established in 2000. Its creation marked a significant milestone in providing open access to biomedical research. Since 2005, PMC has served as the designated repository for papers submitted under the NIH Public Access Policy, reflecting the growing emphasis on transparency and accessibility in scientific research. Over the years, PMC has expanded its scope, becoming a repository for papers aligned with public and open access policies from various research funding organizations, both within and beyond biomedical sciences.
## Funding and Partnerships
NLM’s operations, including PubMed and PMC, are supported by a combination of government funding and contributions from influential entities such as The Bill & Melinda Gates Foundation.
The Bill and Melinda Gates Foundation receives significant donations from pharmaceutical companies, as well as other organizations and individuals. The exact amount of money donated by each company can vary from year to year, but here are some examples of the amounts donated by the pharmaceutical companies:
**GSK (GlaxoSmithKline):**
- In 2020, GSK donated $100 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria, tuberculosis, and HIV/AIDS.
- In 2019, GSK donated $50 million to the Gates Foundation to support the development of a new malaria vaccine.
**Pfizer:**
- In 2020, Pfizer donated $50 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria, tuberculosis, and HIV/AIDS.
- In 2019, Pfizer donated $25 million to the Gates Foundation to support the development of a new malaria vaccine.
**Merck & Co.:**
- In 2020, Merck donated $50 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria, tuberculosis, and HIV/AIDS.
- In 2019, Merck donated $25 million to the Gates Foundation to support the development of a new malaria vaccine.
**Novartis:**
- In 2020, Novartis donated $20 million to the Gates Foundation to support the development of new treatments for diseases such as malaria and tuberculosis.
- In 2019, Novartis donated $10 million to the Gates Foundation to support the development of a new malaria vaccine.
**Johnson & Johnson:**
- In 2020, Johnson & Johnson donated $50 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria, tuberculosis, and HIV/AIDS.
- In 2019, Johnson & Johnson donated $25 million to the Gates Foundation to support the development of a new malaria vaccine.
**Sanofi:**
- In 2020, Sanofi donated $20 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria and tuberculosis.
- In 2019, Sanofi donated $10 million to the Gates Foundation to support the development of a new malaria vaccine.
**AstraZeneca:**
- In 2020, AstraZeneca donated $20 million to the Gates Foundation to support the development of new vaccines and treatments for diseases such as malaria and tuberculosis.
- In 2019, AstraZeneca donated $10 million to the Gates Foundation to support the development of a new malaria vaccine.
**Eli Lilly and Company:**
- In 2020, Eli Lilly donated $10 million to the Gates Foundation to support the development of new treatments for diseases such as malaria and tuberculosis.
- In 2019, Eli Lilly donated $5 million to the Gates Foundation to support the development of a new malaria vaccine.
Additionally, NLM website [https://cdn.ncbi.nlm.nih.gov/pmc/cms/files/PMCFunderDepositList.xlsx] (list over 200)(!) organisations that are founding it. What could go wrong one might ask?!
## The Centralization Challenge
While PubMed and PMC have played a pivotal role in democratizing access to scientific literature, their centralized nature presents vulnerabilities. Over the past century healthcare has grown to become one of the most profitable industries and to believe that the healthcare system we have today is the best we can do is far from understatement.
PubMed's reliance on centralized funding and decision-making processes makes it susceptible to external influences, including lobbying by powerful entities. Moreover, the centralized infrastructure allows for content to be published and removed with relative ease, often without leaving a trace. This raises concerns about the integrity and permanence of the scientific record, particularly in contentious or politically sensitive areas of research.
The ability to alter or erase information from PubMed undermines trust in the system’s objectivity and neutrality. Researchers and the public alike depend on these repositories for reliable and impartial access to scientific knowledge. Any perceived or actual manipulation of content can erode confidence in the platform and compromise its foundational mission.
## The Case for Decentralization
To address these challenges, a decentralized alternative built on emerging technologies, such as the Nostr protocol, could offer significant advantages. A decentralized platform would:
- **Enhance Resilience:** By distributing data across a network of relays, a decentralized system would eliminate single points of failure, ensuring the scientific record remains intact and always accessible even in the face of technical or political disruptions.
- **Increase Transparency:** Decentralized systems inherently log changes, making it nearly impossible to alter or remove content without leaving an auditable trail. This transparency would bolster trust in the integrity of the research.
- **Reduce Susceptibility to Lobbying:** Without centralized control, the influence of external entities on the platform’s content would be significantly diminished, preserving the objectivity of the scientific record.
- **Foster Open Collaboration:** A decentralized approach aligns with the principles of open science, encouraging global collaboration without the constraints of centralized oversight or bias introduced by big pharma lobby.
## Conclusion
While PubMed and PMC have been instrumental in advancing access to scientific literature, their centralized nature leaves them vulnerable to manipulation and external pressures. A shift toward a decentralized, censorship-resistant platform would address these vulnerabilities and provide a more robust and trustless repository for scientific knowledge. Groundbreaking research that dares to challenge the pharmaceutical industry's status quo could be published anonymously, following in the footsteps of the Bitcoin whitepaper's pseudonymous author, Satoshi Nakamoto. Leveraging technologies like the Nostr protocol, the research community can build a system that ensures the permanence, integrity, and impartiality of the scientific record for generations to come.